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Carbon-14 Radiolabelling

What is it?

Carbon-14 radiolabelling is used in AME studies to determine the mass balance of the drug molecule after dose administration.

How does it work?

The radiolabel is introduced to the drug molecule by replacing one or several of the carbon atoms with Carbon-14. This produces a copy of the drug molecule with the same distribution path in the body that contains a radioactive element for quantification. Carbon-14 radiolabelling is used in studies that assess safety in terms of distribution, residence time and metabolism of the molecule.

Why choose Arcinova?

Our collaborative approach enables us to draw on a strong analytical and drug product team, delivering a service that helps our customers through all stages of the drug development process. We also offer GMP compliant radiosynthesis for clinical trial materials.

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