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Our work and case studies

Challenge: MPK and Bioanalysis need to quantify parent and metabolite drug concentrations in biological samples from non-clinical and clinical trials.

Customer:

Multiple, biotechnology and large-pharma

Outcome:

In most cases, a Stable Isotope Labelled (SIL) standard optimises analysis, resulting in a more robust high throughput assay. The SIL has the same chromatographic retention time, extraction properties and stability as the analyte.

SIL use is recommended by the European Medicines Agency (EMA) and the FDA.

 

Stable Isotope Labelling