Coronavirus Update - 14th October 2020

Despite the recent rises in Covid-19 cases throughout the UK and Europe, Arcinova remains open for business at full capacity as we have done throughout this pandemic. As the situation continues to evolve, we will keep all our customers and stakeholders informed of our activities through this web-page which is updated on a regular basis.

We would like to take this opportunity to thank our clients and staff for their continued support over this period of restricted movement. 

We fully comply with all government guidance on minimising the risks of COVID-19 and have published our risk assessment here

Our work and case studies

Challenge: Thermal rearrangement of 7.5 kg of an API intermediate – A technically challenging and labour intensive process in batch with a typical yield of 50% and a poor impurity profile. Reaction conditions: Diphenyl ether, 180°C, 2 hours (followed by acid-base extraction and solvent switch into dichloromethane then ethanol).

Customer:

US Biotech 

Outcome:

The process was run continuously using a coil reactor and superheated ethanol as solvent. The yield and purity of the product were increased. The overall throughput was improved due to a shortened residence time and the number of human manipulations was reduced.               

As a result the implementation of flow led to significant time and cost savings.

 

API Continuous Approach Case Study Pic

Continuous flow case study