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Our work and case studies

Challenge: Rapid development of a scalable route towards an analogue of a new drug substance, with definition of an optimal salt form for formulation


US Biotech client developing combined Small Molecule / Biologic immunotherapy treatments


ARCINOVA developed two process route options and selected one on the basis of scalability and process economy. The API free base was generated and a rapid salt screening protocol undertaken. A solubility study was undertaken which showed optimal solubilisation at a set pH. The client was delighted and has filed provisional IP. The drug substance analogue shows superior solubility to the prime API.


API Development Case Study BEL