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Radiosynthesis Chemists x2

Date Posted: 06/05/2021
Application Close: 31/05/2021
Location: Arcinova - Alnwick

An exciting opportunity has arisen for two Radiosynthesis Chemist to join the Isotopic Labelling team to work within an expanding team at our Alnwick site. 

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Job Description

An exciting opportunity has arisen for two Radiosynthesis Chemist to join the Isotopic Labelling team to work within an expanding team at our Alnwick site.

Key Responsibilities:

  • Plan and perform syntheses and purifications of various chemical and/or labelled chemical entities within agreed timeframes.
  • Maintain Laboratory Notebooks, prepare Analytical Data Sheets and reports.
  • Design synthetic routes.
  • Prepare cost estimates and client proposals with assistance and in collaboration with BD.
  • Liaise with clients to facilitate the award of projects to Isotopic Labelling. 
  • Capable of acting as Project Manager for small scale syntheses as assigned.
  • Manufacture radio and stable isotopically labelled intermediates and API at the milligram to low gram scale. 
  • Apply the skills highlighted above to the manufacture of non-pharmaceutical materials, impurities, and degradation products at the milligram to low gram scale for labelled compounds.
  • Perform in-process analytical testing where relevant and/or ensure that analytical, microbiological (where relevant) and materials science/spectroscopic testing needs are discussed and agreed with the CMC team.
  • Contribute to laboratory operations, equipment acquisition and maintenance, contracts, housekeeping, stock control, disposals and liaise with other departments dealing with such matters.
  • Ensure, where required, that laboratory work and associated documentation complies with GMP or other regulatory requirements, internal policies/procedures, and client requirements.
  • Work with due regard to health & safety of self and others.
  • Work flexibly across the site to meet business needs.

Key Skills:

  • Knowledge and experience of synthetic chemistry covering route selection.
  • Full awareness of the current regulatory environment
  • A comprehensive understanding of process analytical chemistry, impurity control and/or sufficient analytical skills to conduct in-process testing.
  • A good understanding of the factors controlling API physical form.
  • Good written and oral communication skills. 

Will require training on Isotope Labelling (14C and synthesis / compliance techniques). Requires regular supervision from team leader and mentoring from designated team members. An excellent record in Synthetic organic chemistry, either at Doctoral level or Graduate with minimum of one year’s relevant industrial experience.

To apply please email your letter of application, CV and any relevant supporting documents to Kate Emanuel.

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