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Operations Chemist

Date Posted: 23/10/2018
Application Close: 29/3/2019
Location: Arcinova - Alnwick
Description:

Perform and manage chemical syntheses in accordance with regulatory and company procedures. Support scale up and manufacturing phases of product development including the provision of shift cover as required.  In-process analysis, including sample preparation and interpretation.  Use test of critical raw materials and intermediates.  Participation in and preparation of HAZOP and risk assessments. 

  • Perform syntheses and purifications of various chemical entities within agreed timeframes. Maintain Laboratory Notebooks of Batch Synthesis Instructions, prepare Analytical Data Sheets and reports.   
  • Manufacture API at the tens of grams to tens of kilogram scale.  Provide manufacturing shift cover as required.
  • Apply the skills highlighted above to the manufacture of non-pharmaceutical materials, impurities and degradation products at the tens of grams to tens of kilogram scale. 
  • Perform in-process analytical testing where relevant and/or ensure that analytical, microbiological (where relevant) and materials science/spectroscopic testing needs are discussed and agreed with the CMC team.
  • Contribute to laboratory operations, equipment acquisition and maintenance, contracts, housekeeping, stock control, disposals and liaise with other departments dealing with such matters. 
  • Ensure, where required, that laboratory work and associated documentation complies with GMP or other regulatory requirements, internal policies/procedures and client requirements,
  • Work with due regard to health &safety of self and others.
  • Work flexibly across the site to meet business needs.

Good knowledge and experience of synthetic chemistry covering process optimisation to ensure successful and cost-effective scale-up. Good understanding of process safety and hazard operability. Proficiency in carrying out kilo-scale chemical processing. Awareness of the current regulatory environment, a comprehensive understanding of process analytical chemistry, impurity control and/or sufficient analytical skills to conduct in-process testing and a good understanding of the factors controlling API physical form. Good written and oral communication skills.  

Either a degree level (or equivalent) qualification in Chemistry or a closely related discipline or a completed apprenticeship as a chemical operator,  with minimum of one year’s relevant industrial experience.