Case Studies
Thermal Rearrangement - Continuous Flow Case Study
CASE STUDY: Thermal Rearrangement - A Continuous Approach
Challenge:
Thermal rearrangement of 7.5 kg of an API intermediate – A technically challenging and labour intensive process in batch with a typical yield of 50% and a poor impurity profile. Reaction conditions: Diphenyl ether, 180°C, 2 hours (followed by acid-base extraction and solvent switch into dichloromethane then ethanol).
Customer:
US Biotech
Outcome:
The process was run continuously using a coil reactor and superheated ethanol as solvent. The yield and purity of the product were increased. The overall throughput was improved due to a shortened residence time and the number of human manipulations was reduced.
As a result the implementation of flow led to significant time and cost savings.
Upcoming
Events
Upcoming Events
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CED Life Science
The CED Life Science Conference will be attended by Masha Kononov, Senior Director Emerging Pharma US and Gail Frey, Senior Director Key Accounts US.CED Life Science
Dates: 26th - 27th FebruaryLocation: Raleigh, NC -
Drug Delivery & Formulation Summit
The DDF Summit 2019 will be attended by Dr. Nathalie Huther, Business Development Manager Europe.Drug Delivery & Formulation Summit
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BioEurope Spring
BioEurope Spring will be attended by Dr. Nathalie Huther, Business Development Manager Europe.BioEurope Spring
Dates: 25th - 27th MarchLocation: Vienna, Austria